Abstract

The issues of increasing life span and significant improvement in its quality are relevant for modern gerontology. The review discusses one of the proposed methods to slow the aging of an organism via the transfusion of blood or plasma from young people to senile ones. Information on the structure, properties, and functions of TIMP-2, MANF, and irisin protein growth factors, which are contained in large amounts in the blood of young organisms, is presented. Experiments on animals showed an increase in their life span and improvement of their cognitive abilities under the effect of these factors. They are of great importance for the enhancement of neurogenesis in the brain, improvement of the cardiovascular and immune system functions, and cancer prevention. The relationship between the high content of irisin in the blood of young organisms and telomere lengthening, its role in eliminating signs of Alzheimer’s disease, mouse modeling, and the elimination of cerebrovascular ischemia were revealed. The administration of umbilical cord blood with a high TIMP-2 content to old mice improves synaptic plasticity and cognitive functions. Further research on the geroprotection effects of blood transfusions from young organisms to aging ones shows promise for the creation of drugs based on these proteins for the treatment of neurodegenerative diseases and cerebrovascular pathology.

中文翻译：

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MANF，TIMP-2和鸢尾素蛋白在衰老中的作用

摘要

寿命延长和质量显着提高的问题与现代老年病学有关。这篇综述讨论了通过从年轻人到老年人的血液或血浆输注来减缓生物体衰老的一种建议方法。介绍了有关年轻动物的血液中大量包含的TIMP-2，MANF和虹膜素蛋白生长因子的结构，性质和功能的信息。在动物身上进行的实验表明，在这些因素的影响下，它们的寿命得以延长，认知能力得到改善。它们对于增强大脑中的神经发生，改善心血管和免疫系统功能以及预防癌症非常重要。揭示了年轻生物体血液中鸢尾素的高含量与端粒延长，其在消除阿尔茨海默氏病征象中的作用，小鼠模型与消除脑血管缺血之间的关系。向老年小鼠施用具有高TIMP-2含量的脐带血可改善突触可塑性和认知功能。从年轻生物到衰老的输血对神经保护作用的进一步研究表明，有望创造出基于这些蛋白质的药物来治疗神经退行性疾病和脑血管病理。向老年小鼠施用具有高TIMP-2含量的脐带血可改善突触可塑性和认知功能。从年轻生物到衰老的输血对神经保护作用的进一步研究表明，有望创造出基于这些蛋白质的药物来治疗神经退行性疾病和脑血管病理。向老年小鼠施用具有高TIMP-2含量的脐带血可改善突触可塑性和认知功能。从年轻生物到衰老的输血对神经保护作用的进一步研究表明，有望创造出基于这些蛋白质的药物来治疗神经退行性疾病和脑血管病理。