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Role of MANF, TIMP-2, and Irisin Proteins in Aging

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Abstract

The issues of increasing life span and significant improvement in its quality are relevant for modern gerontology. The review discusses one of the proposed methods to slow the aging of an organism via the transfusion of blood or plasma from young people to senile ones. Information on the structure, properties, and functions of TIMP-2, MANF, and irisin protein growth factors, which are contained in large amounts in the blood of young organisms, is presented. Experiments on animals showed an increase in their life span and improvement of their cognitive abilities under the effect of these factors. They are of great importance for the enhancement of neurogenesis in the brain, improvement of the cardiovascular and immune system functions, and cancer prevention. The relationship between the high content of irisin in the blood of young organisms and telomere lengthening, its role in eliminating signs of Alzheimer’s disease, mouse modeling, and the elimination of cerebrovascular ischemia were revealed. The administration of umbilical cord blood with a high TIMP-2 content to old mice improves synaptic plasticity and cognitive functions. Further research on the geroprotection effects of blood transfusions from young organisms to aging ones shows promise for the creation of drugs based on these proteins for the treatment of neurodegenerative diseases and cerebrovascular pathology.

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Authors and Affiliations

  1. Chita State Medical Academy, Chita, Russia

    B. I. Kuznik & S. O. Davidov

  2. Academy of Health Innovation Clinic, Chita, Russia

    B. I. Kuznik & S. O. Davidov

  3. St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia

    N. I. Chalisova

  4. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia

    N. I. Chalisova

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  1. B. I. Kuznik
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  2. S. O. Davidov
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Kuznik, B.I., Davidov, S.O. & Chalisova, N.I. Role of MANF, TIMP-2, and Irisin Proteins in Aging. Biol Bull Rev 10, 285–295 (2020). https://doi.org/10.1134/S2079086420040052

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