Abstract

The present study emphasizes the fabrication of thermal and pH-responsive photo-cross-linked polymers and hydrogel thin films. N-isopropylacrylamide was used as a thermal responsive monomer, while a new pH-responsive monomer was synthesized based on vanillin 2-((dimethylamino)methyl)-4-formyl-6-methoxyphenyl acrylate (DMAMVA). The photo-cross-linker (DMIA) and adhesion promotor (DMITAAc) have been prepared. All compounds were investigated by 1H NMR, 13C NMR, and FTIR. Terpolymers of 10, 15, and 20 mol% DMAMVA and 10 mol% of DMIA with N-isopropylacrylamide were fabricated. The chemical structures were investigated, and the molecular weights were determined by gel permeation chromatography GPC. Moreover, the glass transition temperatures were also recorded by differential scanning calorimeter DSC. The lower critical solution temperatures of polymers were determined by turbidity tests using UV–Vis spectroscopy. The polymer solution of 20 mol% sample was spin-coated over the gold to form hydrogel thin film within photo-cross-linking by the UV lamp. The film thickness was determined by the SPR-OW technique using Kretschmann configuration. The swelling was recorded and the transition temperature of hydrogel was determined as the change in volume degree of swelling and refractive index with the change in temperature. The dual responsive functional photo-cross-linked polymers and hydrogel thin films have significant importance in the grafting of some biological molecules.

Graphic Abstract

中文翻译：

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香兰素丙烯酸酯衍生物对环境光交联N-异丙基丙烯酰胺共聚物和水凝胶薄膜相分离温度的影响

摘要

本研究强调热和pH响应的光交联聚合物和水凝胶薄膜的制造。N-异丙基丙烯酰胺用作热响应性单体，而基于香草醛2-（（二甲基氨基）甲基）-4-甲酰基-6-甲氧基苯基丙烯酸酯（DMAMVA）合成了新的pH响应单体。已制备了光交联剂（DMIA）和粘合促进剂（DMITAAc）。所有化合物均通过1 H NMR，13 C NMR和FTIR研究。制备了10、15和20mol％的DMAMVA和10mol％的DMIA与N-异丙基丙烯酰胺的三元共聚物。研究了化学结构，并通过凝胶渗透色谱GPC确定分子量。此外，玻璃化转变温度也通过差示扫描量热仪DSC记录。聚合物的最低临界溶液温度通过使用UV-Vis光谱的浊度测试确定。将20mol％样品的聚合物溶液旋涂在金上，以通过UV灯在光交联内形成水凝胶薄膜。膜厚度通过使用Kretschmann构型的SPR-OW技术确定。记录溶胀并确定水凝胶的转变温度为溶胀的体积度和折射率随温度的变化。具有双响应功能的光交联聚合物和水凝胶薄膜在某些生物分子的接枝中具有重要意义。将20mol％样品的聚合物溶液旋涂在金上，以通过UV灯在光交联内形成水凝胶薄膜。膜厚度通过使用Kretschmann构型的SPR-OW技术确定。记录溶胀并确定水凝胶的转变温度为溶胀的体积度和折射率随温度的变化。具有双响应功能的光交联聚合物和水凝胶薄膜在某些生物分子的接枝中具有重要意义。将20mol％样品的聚合物溶液旋涂在金上，以通过UV灯在光交联内形成水凝胶薄膜。膜厚度通过使用Kretschmann构型的SPR-OW技术确定。记录溶胀并确定水凝胶的转变温度为溶胀的体积度和折射率随温度的变化。具有双响应功能的光交联聚合物和水凝胶薄膜在某些生物分子的接枝中具有重要意义。

图形摘要