Fibro-porous PLLA/gelatin composite membrane doped with cerium oxide nanoparticles as bioactive scaffolds for future angiogenesis.,Journal of Materials Chemistry B

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Fibro-porous PLLA/gelatin composite membrane doped with cerium oxide nanoparticles as bioactive scaffolds for future angiogenesis.
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-08-24 , DOI: 10.1039/d0tb01715a
Zhiyang Xu ₁ , Yulong Xu ₁ , Papia Basuthakur ₂ , Chitta Ranjan Patra ₂ , Seeram Ramakrishna ₃ , Yong Liu ₁ , Vinoy Thomas ₄ , Himansu Sekhar Nanda ₅

Affiliation

Functionalized cerium oxide nanoparticle (CeNP)-loaded fibro-porous poly-L-lactic acid (PLLA)/gelatin composite membranes were prepared via an electrospinning technology. Considering the importance of such membrane scaffolds for promoting angiogenesis in tissue engineering and drug screening, a series of PLLA/gelatin composite fiber membranes loaded with different doses of CeNPs was prepared. The prepared composite membranes demonstrated hydrophilicity, water absorption, and improved mechanical properties compared to a PLLA and PLLA/gelatin membrane. Also, cell viability assay using somatic hybrid endothelial cells (EA.hy926) proved the biocompatible nature of the scaffolds. The biocompatibility was further supported by in vivo chick embryo angiogenesis assay using fertilized eggs. Our initial results support that these membrane scaffolds could be useful for angiogenesis-related disease treatment after further investigations.

中文翻译：

纤维孔 PLLA/明胶复合膜掺杂氧化铈纳米颗粒作为未来血管生成的生物活性支架。

采用静电纺丝技术制备了功能化氧化铈纳米颗粒（CeNP）负载纤维孔聚左旋乳酸（PLLA）/明胶复合膜。考虑到这种膜支架在组织工程和药物筛选中促进血管生成的重要性，制备了一系列负载不同剂量CeNPs的PLLA/明胶复合纤维膜。与 PLLA 和 PLLA/明胶膜相比，制备的复合膜具有亲水性、吸水性和改善的机械性能。此外，使用体细胞杂交内皮细胞（EA.hy926）的细胞活力测定证明了支架的生物相容性。使用受精卵进行的体内鸡胚血管生成测定进一步支持了生物相容性。我们的初步结果表明，经过进一步研究，这些膜支架可用于血管生成相关疾病的治疗。

更新日期：2020-10-14

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