Fibro-porous PLLA/gelatin composite membrane doped with cerium oxide nanoparticles as bioactive scaffolds for future angiogenesis

Zhiyang Xu; Yulong Xu; Papia Basuthakur; Chitta Ranjan Patra; Seeram Ramakrishna; Yong Liu; Vinoy Thomas; Himansu Sekhar Nanda

doi:10.1039/D0TB01715A

Fibro-porous PLLA/gelatin composite membrane doped with cerium oxide nanoparticles as bioactive scaffolds for future angiogenesis†

Zhiyang Xu,^a Yulong Xu,^a Papia Basuthakur,

^bc Chitta Ranjan Patra,

^bc Seeram Ramakrishna,

^d Yong Liu,

*^a Vinoy Thomas

^e and Himansu Sekhar Nanda

*^f

Author affiliations

* Corresponding authors

^a College of Material Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China
E-mail: yongliu@mail.buct.edu.cn
Tel: +86-135-2100-8075

^b Applied Biology Department, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad-500007, Telangana State, India

^c Academy of Scientific & Innovative Research (AcSIR), Ghaziabad-201002, India

^d Centre for Nanofibers and Nanotechnology, Department of Mechanical Engineering, National University of Singapore, Singapore 117575, Singapore

^e Department of Materials Science and Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA

^f Biomedical Engineering and Technology Laboratory, Discipline of Mechanical Engineering, PDPM-Indian Institute of Information Technology Design and Manufacturing, Jabalpur, Dumna Airport Road, Jabalpur-482005, MP, India
E-mail: himansu@iiitdmj.ac.in
Tel: +91-761-2794-429

Abstract

Functionalized cerium oxide nanoparticle (CeNP)-loaded fibro-porous poly-L-lactic acid (PLLA)/gelatin composite membranes were prepared via an electrospinning technology. Considering the importance of such membrane scaffolds for promoting angiogenesis in tissue engineering and drug screening, a series of PLLA/gelatin composite fiber membranes loaded with different doses of CeNPs was prepared. The prepared composite membranes demonstrated hydrophilicity, water absorption, and improved mechanical properties compared to a PLLA and PLLA/gelatin membrane. Also, cell viability assay using somatic hybrid endothelial cells (EA.hy926) proved the biocompatible nature of the scaffolds. The biocompatibility was further supported by in vivo chick embryo angiogenesis assay using fertilized eggs. Our initial results support that these membrane scaffolds could be useful for angiogenesis-related disease treatment after further investigations.

Supplementary files

Article information

DOI: https://doi.org/10.1039/D0TB01715A
Article type: Paper
Submitted: 11 Jul 2020
Accepted: 24 Aug 2020
First published: 24 Aug 2020

Download Citation

J. Mater. Chem. B, 2020,8, 9110-9120

Permissions

Request permissions

Fibro-porous PLLA/gelatin composite membrane doped with cerium oxide nanoparticles as bioactive scaffolds for future angiogenesis

Z. Xu, Y. Xu, P. Basuthakur, C. R. Patra, S. Ramakrishna, Y. Liu, V. Thomas and H. S. Nanda, J. Mater. Chem. B, 2020, 8, 9110 DOI: 10.1039/D0TB01715A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Journal of Materials Chemistry B

Fibro-porous PLLA/gelatin composite membrane doped with cerium oxide nanoparticles as bioactive scaffolds for future angiogenesis†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Fibro-porous PLLA/gelatin composite membrane doped with cerium oxide nanoparticles as bioactive scaffolds for future angiogenesis

Social activity

Search articles by author

Spotlight

Advertisements