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Alterchromanone A, one new chromanone derivative from the mangrove endophytic fungus Alternaria longipes.
The Journal of Antibiotics ( IF 2.1 ) Pub Date : 2020-08-25 , DOI: 10.1038/s41429-020-00364-4
Gaoran Liu 1, 2 , Shubin Niu 3 , Ling Liu 1
Affiliation  

One new chromanone derivative, alterchromanone A (1), and four known curvularin-type macrolides (25) were isolated from the crude extract of the mangrove-derived endophytic fungus Alternaria longipes. Their structures were elucidated by MS and NMR spectroscopic analyses and by a comparison with data from the literature. The absolute configuration of 1 was assigned by combination of experimental and calculated electronic circular dichroism (ECD) spectra. Compound 1 exhibited 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity with an IC50 value of 56.3 μg ml−1. According to the structural features of these compounds, the plausible biosynthetic pathways of 15 were also proposed.



中文翻译:

Alterchromanone A,一种来自红树林内生真菌 Alternaria longipes 的新色满酮衍生物。

一个新的苯并二氢吡喃衍生物,alterchromanone A(1),和四个已知curvularin型大环内酯类(2 - 5)从红树林衍生内生真菌的粗提取物中分离烟草赤星病菌。它们的结构通过 MS 和 NMR 光谱分析以及与文献数据的比较来阐明。的绝对构型1,通过试验的和计算电子圆二色性(ECD)光谱的组合分配。化合物1表现出1,1-二苯基-2-苦基肼(DPPH)自由基清除活性,IC 50值为56.3 μg ml -1. 根据这些化合物的结构特征,的似是而非的生物合成途径1 - 5还提出。

更新日期:2020-08-25
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