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Alterchromanone A, one new chromanone derivative from the mangrove endophytic fungus Alternaria longipes

The Journal of Antibiotics volume 74, pages 152–155 (2021)Cite this article

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Abstract

One new chromanone derivative, alterchromanone A (1), and four known curvularin-type macrolides (2–5) were isolated from the crude extract of the mangrove-derived endophytic fungus Alternaria longipes. Their structures were elucidated by MS and NMR spectroscopic analyses and by a comparison with data from the literature. The absolute configuration of 1 was assigned by combination of experimental and calculated electronic circular dichroism (ECD) spectra. Compound 1 exhibited 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity with an IC50 value of 56.3 μg ml−1. According to the structural features of these compounds, the plausible biosynthetic pathways of 1–5 were also proposed.

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Fig. 1
Fig. 2
Scheme 1

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Acknowledgements

This work was supported by the National Key R&D Program of China (2018YFC0311002) and the National Natural Science Foundation of China (21772228 and 21977113).

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Authors and Affiliations

  1. State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, 100101, Beijing, China

    Gaoran Liu & Ling Liu

  2. University of Chinese Academy of Sciences, 100039, Beijing, China

    Gaoran Liu

  3. School of Biological Medicine, Beijing City University, 100083, Beijing, China

    Shubin Niu

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  1. Gaoran Liu
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  2. Shubin Niu
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Correspondence to Ling Liu.

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Liu, G., Niu, S. & Liu, L. Alterchromanone A, one new chromanone derivative from the mangrove endophytic fungus Alternaria longipes. J Antibiot 74, 152–155 (2021). https://doi.org/10.1038/s41429-020-00364-4

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