Cellular internalization mechanism of novel Raman probes designed for plant cells,RSC Chemical Biology

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Cellular internalization mechanism of novel Raman probes designed for plant cells
RSC Chemical Biology ( IF 4.2 ) Pub Date : 2020-08-20 , DOI: 10.1039/d0cb00128g
Keiko Midorikawa ₁ , Kousuke Tsuchiya _{1,

2} , Simon Sau Yin Law ₁ , Yu Miyagi ₁ , Takuya Asai ₃ , Takanori Iino ₃ , Yasuyuki Ozeki ₃ , Yutaka Kodama _{1,

4} , Keiji Numata _{1,

2}

Affiliation

Diphenylacetylene derivatives containing different polymeric components, poly(L-lysine) (pLys) or tetra(ethylene glycol) (TEG) were designed as novel Raman imaging probes with high Raman sensitivity and low cytotoxicity in living plant cells. The pLys-conjugated probe is internalized via an endocytosis-dependent pathway, whereas TEG-conjugated probe most likely induces direct penetration into the plant cells.

中文翻译：

为植物细胞设计的新型拉曼探针的细胞内化机制

含有不同聚合物成分的二苯乙炔衍生物，聚（L-赖氨酸）（pLys）或四（乙二醇）（TEG）被设计为新型拉曼成像探针，在活植物细胞中具有高拉曼灵敏度和低细胞毒性。pLys 偶联探针通过内吞作用依赖途径内化，而 TEG 偶联探针最有可能诱导直接渗透到植物细胞中。

更新日期：2020-10-08

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