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Metabolic Drivers in Hereditary Cancer Syndromes
Annual Review of Cancer Biology ( IF 4.7 ) Pub Date : 2020-03-09 , DOI: 10.1146/annurev-cancerbio-030419-033612
Marco Sciacovelli 1 , Christina Schmidt 1 , Eamonn R. Maher 2 , Christian Frezza 1
Affiliation  

Cancer is a multifaceted disease in which inherited genetic variants can be important drivers of tumorigenesis. The discovery that germline mutations of metabolic genes predispose to familial forms of cancer caused a shift in our understanding of how metabolism contributes to tumorigenesis, providing evidence that metabolic alterations can be oncogenic. In this review, we focus on mitochondrial enzymes whose mutations predispose to familial cancer, and we fully appraise their involvement in cancer formation and progression. Elucidating the molecular mechanisms that orchestrate transformation in these diverse tumors may answer key biological questions about tumor formation and evolution, leading to the identification of new therapeutic targets of intervention.

中文翻译:


遗传性癌症综合征的代谢驱动因素

癌症是多方面的疾病,其中遗传的遗传变异可能是肿瘤发生的重要驱动力。代谢基因的种系突变易患家族性癌症的发现引起了我们对代谢如何促进肿瘤发生的认识的转变,提供了代谢改变可能是致癌性的证据。在这篇综述中,我们关注突变易导致家族性癌症的线粒体酶,并充分评估其参与癌症形成和发展的过程。阐明在这些不同肿瘤中协调转化的分子机制可能会回答有关肿瘤形成和进化的关键生物学问题,从而确定新的干预治疗靶标。

更新日期:2020-03-09
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