当前位置: X-MOL 学术Pharm. Chem. J. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Peculiarities of Determining Bacterial Endotoxins in Oil Solutions of Drugs
Pharmaceutical Chemistry Journal ( IF 0.8 ) Pub Date : 2020-08-01 , DOI: 10.1007/s11094-020-02234-7
O. V. Shapovalova , N. P. Neugodova , G. A. Sapozhnikova

Issues related to reliable quality assessment of oil solutions of medicines with respect to the Bacterial Endotoxins indicator are considered. The maximum isolation of bacterial endotoxins from fat-soluble drugs for subsequent determination is assisted by vigorous stirring of samples in water previously heated to 60°C followed by separation of the two phases using centrifugation at 2300 rpm for 10 min.

中文翻译:

药物油溶液中细菌内毒素测定的特点

考虑了与细菌内毒素指标相关的药物油溶液的可靠质量评估相关的问题。通过在预先加热至 60°C 的水中剧烈搅拌样品,然后使用 2300 rpm 离心 10 分钟分离两相,有助于从脂溶性药物中最大程度地分离细菌内毒素以用于后续测定。
更新日期:2020-08-01
down
wechat
bug