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Peculiarities of Determining Bacterial Endotoxins in Oil Solutions of Drugs

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Pharmaceutical Chemistry Journal Aims and scope

Issues related to reliable quality assessment of oil solutions of medicines with respect to the Bacterial Endotoxins indicator are considered. The maximum isolation of bacterial endotoxins from fat-soluble drugs for subsequent determination is assisted by vigorous stirring of samples in water previously heated to 60°C followed by separation of the two phases using centrifugation at 2300 rpm for 10 min.

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Acknowledgments

The work was performed in the framework of a State Task for SCEEMP, Ministry of Health of Russia, No. 056-00154-19-00 for applied scientific research (State Acct. No. NIR AAAA-A18-118021590049-0).

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Authors and Affiliations

  1. Scientific Center for Expert Evaluation of Medicinal Products, Ministry of Health of the Russian Federation, 8/2 Petrovskii Blvd., Moscow, 127051, Russia

    O. V. Shapovalova, N. P. Neugodova & G. A. Sapozhnikova

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  1. O. V. Shapovalova
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  2. N. P. Neugodova
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  3. G. A. Sapozhnikova
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 54, No. 5, pp. 58 – 61, May, 2020.

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Shapovalova, O.V., Neugodova, N.P. & Sapozhnikova, G.A. Peculiarities of Determining Bacterial Endotoxins in Oil Solutions of Drugs. Pharm Chem J 54, 539–543 (2020). https://doi.org/10.1007/s11094-020-02234-7

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  • DOI: https://doi.org/10.1007/s11094-020-02234-7

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