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Synthesis and Anti-Aggregation Activity of 2-[3-Methyl-1-Ethylxanth-8-Ylthio]Acetate Salts Containing Thietanyl and Dioxothietanyl Rings
Pharmaceutical Chemistry Journal ( IF 0.8 ) Pub Date : 2020-08-01 , DOI: 10.1007/s11094-020-02220-z
K. G. Gurevich , A. L. Urakov , F. A. Khaliullin , A. V. Samorodov , Yu. V. Shabalina , F. Kh. Kamilov , D. Z. Murataev , L. I. Bashirova

Reactions of 2-[1-ethyl-3-methyl-7-(thietan-3-yl)- and 2-[1-ethyl-3-methyl-7-(1,1-dioxothietan-3-yl)xanth- 8-ylthio]acetic acids with amines (diethylamine, monoethanolamine, diethanolamine, triethanolamine, piperidine, cyclohexylamine, and benzylamine) gave 42 – 89% yields of 2-[1-ethyl-3-methyl-xanth-8-ylthio]- acetate salts containing thietanyl and dioxothietanyl rings. The structures of the synthesized compounds were confirmed using IR and PMR spectroscopy. The synthesized compounds exhibited anti-aggregation activity.

中文翻译:

含有硫杂环丁烷和二氧杂硫杂环丁烷的 2-[3-Methyl-1-Ethylxanth-8-Ylthio]Acetate 盐的合成和抗聚集活性

2-[1-乙基-3-甲基-7-(thietan-3-yl)-和2-[1-ethyl-3-methyl-7-(1,1-dioxothietan-3-yl)xanth-的反应8-基硫基]乙酸与胺(二乙胺、单乙醇胺、二乙醇胺、三乙醇胺、哌啶、环己胺和苄胺)的 2-[1-乙基-3-甲基-黄原-8-基硫基]-乙酸的产率为 42 – 89%含有硫杂环丁烷和二氧杂杂环丁烷环的盐。合成化合物的结构通过IR和PMR光谱证实。合成的化合物表现出抗聚集活性。
更新日期:2020-08-01
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