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Synthesis and Anti-Aggregation Activity of 2-[3-Methyl-1-Ethylxanth-8-Ylthio]Acetate Salts Containing Thietanyl and Dioxothietanyl Rings

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Pharmaceutical Chemistry Journal Aims and scope

Reactions of 2-[1-ethyl-3-methyl-7-(thietan-3-yl)- and 2-[1-ethyl-3-methyl-7-(1,1-dioxothietan-3-yl)xanth- 8-ylthio]acetic acids with amines (diethylamine, monoethanolamine, diethanolamine, triethanolamine, piperidine, cyclohexylamine, and benzylamine) gave 42 – 89% yields of 2-[1-ethyl-3-methyl-xanth-8-ylthio]- acetate salts containing thietanyl and dioxothietanyl rings. The structures of the synthesized compounds were confirmed using IR and PMR spectroscopy. The synthesized compounds exhibited anti-aggregation activity.

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References

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Authors and Affiliations

  1. A. I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of the Russian Federation, 20/1 Delegatskaya St, Moscow, 127473, Russia

    K. G. Gurevich

  2. Udmurt Federal Research Center, Ural Branch, Russian Academy of Sciences, 67 Tat’yany Baramzinoi St, Izhevsk, Udmurtia, 426067, Russia

    A. L. Urakov

  3. Bashkir State Medical University, Ministry of Health of the Russian Federation, 3 Lenina St, Ufa, Bashkortostan, 450008, Russia

    F. A. Khaliullin, A. V. Samorodov, Yu. V. Shabalina, F. Kh. Kamilov & D. Z. Murataev

  4. Izhevsk State Medical Academy, Ministry of Health of the Russian Federation, 281 Kommunarov St, Izhevsk, Udmurtia, 426034, Russia

    L. I. Bashirova

Authors
  1. K. G. Gurevich
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  2. A. L. Urakov
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  3. F. A. Khaliullin
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  4. A. V. Samorodov
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  5. Yu. V. Shabalina
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  6. F. Kh. Kamilov
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  7. D. Z. Murataev
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  8. L. I. Bashirova
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Corresponding author

Correspondence to A. L. Urakov.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 54, No. 5, pp. 16 – 20, May, 2020.

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Gurevich, K.G., Urakov, A.L., Khaliullin, F.A. et al. Synthesis and Anti-Aggregation Activity of 2-[3-Methyl-1-Ethylxanth-8-Ylthio]Acetate Salts Containing Thietanyl and Dioxothietanyl Rings. Pharm Chem J 54, 444–448 (2020). https://doi.org/10.1007/s11094-020-02220-z

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  • DOI: https://doi.org/10.1007/s11094-020-02220-z

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