Chitosan hydrogels containing the antiviral drug megosine were prepared. The conditions (concentrations of polymer solution, cross-linking agent, and drug substance) were selected so that the hydrogel could be formed without separating the liquid phase. The possibility for prolonged release of megosine from the developed chitosan hydrogel was demonstrated. Megosine in the hydrogels administered vaginally did not penetrate into blood and organs. The release kinetics of megosine from the chitosan hydrogels were studied and showed 59% release of megosine from the hydrogel in 7 h.

中文翻译：

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含甲高辛的壳聚糖基水凝胶组合物

制备了含有抗病毒药物美高辛的壳聚糖水凝胶。选择条件（聚合物溶液、交联剂和药物的浓度），以便可以在不分离液相的情况下形成水凝胶。证明了从开发的壳聚糖水凝胶中延长释放 megosine 的可能性。阴道给药的水凝胶中的美高辛没有渗透到血液和器官中。研究了甲高辛从壳聚糖水凝胶中的释放动力学，并表明在 7 小时内从水凝胶中释放了 59% 的甲高辛。