Skip to main content

Advertisement

SpringerLink
Log in

Chitosan-Based Hydrogel Composition with Megosine

  • Published:
Pharmaceutical Chemistry Journal Aims and scope

Chitosan hydrogels containing the antiviral drug megosine were prepared. The conditions (concentrations of polymer solution, cross-linking agent, and drug substance) were selected so that the hydrogel could be formed without separating the liquid phase. The possibility for prolonged release of megosine from the developed chitosan hydrogel was demonstrated. Megosine in the hydrogels administered vaginally did not penetrate into blood and organs. The release kinetics of megosine from the chitosan hydrogels were studied and showed 59% release of megosine from the hydrogel in 7 h.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.
Fig. 3.

Similar content being viewed by others

References

  1. A. Sauerbrei, Infect. Drug Resist., 9, 129 – 141 (2016).

    Article  Google Scholar 

  2. V. A. Akovbyan, S. A. Masyukova, and E. V. Vladimirova, Klin. Mikrobiol. Antimikrob. Khimioter., 5(1), 4 – 18 (2003).

    Google Scholar 

  3. V. A. Isakov, A. L. Kovalenko, and A. R. Romantsov, Klin. Med., 3, 54 – 57 (2011).

    Google Scholar 

  4. V. A. Isakov and D. V. Isakov, Klin. Med., 4, 16 – 24 (2015).

    Google Scholar 

  5. N. V. Shperling and A. V. Sharopina, Sib. Med. Zh., 24(1 – 2), 104 – 107 (2009).

    Google Scholar 

  6. PM on megosine drug substance (PM 42 Uz-0103-2015), on reference standard (PM 42 Uz-0102-2015), on megosine ointment 1% (PM 42 Uz-0648-2007).

  7. N. I. Baram, A. I. Ismailov, Kh. L. Ziyaev, and K. Zh. Rezhepov, Khim. Prir. Soedin., 3, 171 – 176 (2004).

    Google Scholar 

  8. V. M. Zhdanov, Kh A. Aslanov, F. M. Ershov, et al., USSR Pat. 1,062,919, 1977.

  9. A. H. Kutscher, E. V. Zegarelli, F. E. Beube, et al., Oral Surg. Oral Med. Oral Pathol., 12, 1080 – 1089 (1959).

    Article  CAS  Google Scholar 

  10. K. G. Skryabin, G. A. Vikhorevaya, and V. P. Varlamov, Chitin and Chitosan. Production, Properties and Application [in Russian], Nauka, Moscow (2002).

    Google Scholar 

  11. A. A. Grishin, N. V. Zorina, and V. I. Lutskii, Izv. Vyssh. Uchebn. Zaved., Prikl. Khim. Biotekhnol., 1(6), 29 – 34 (2014).

    Google Scholar 

  12. M. Sato, H. Onishi, and J. Takahara, Biol. Pharm. Bull., 19(9), 1170 – 1177 (1996).

    Article  CAS  Google Scholar 

  13. T. A. Sonia and C. P. Sharma, Adv. Polym. Sci., 243, 23 – 53 (2011).

    Article  CAS  Google Scholar 

  14. I. Aranaz, M. Mengíbar, R. Harris, et al., Curr. Chem. Biol., 3, 203 – 230 (2009).

    CAS  Google Scholar 

  15. S. Kumar, React. Funct. Polym., 46, 1 – 27(2000).

    Article  CAS  Google Scholar 

  16. S. K. Yellanki, N. K. Nerella, S. Goranti, and S. Kumar, Int. J. PharmTech Res., 3, 1746 – 1750 (2010).

    Google Scholar 

  17. F. Ahmadi, Z. Oveisi, S. M. Samani, and Z. Amoozgar, Carbohydr. Polym., 106, 109 – 120 (2014).

    Article  Google Scholar 

  18. Z. Oveisi, S. M. Samani, and Z. Amoozgar, Res. Pharm. Sci., Jan-Feb, 10(1), 1 – 16 (2015).

  19. European Convention for the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes (1986); http: // www.lawmix.ru / abro.php?id=11036.

  20. R. R. Vil’danova, N. N. Sigaeva, E. A. Fayanova, et al., Vestn. Bashkir. Univ., 22(1), 72 – 76 (2017).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. A. S. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan, 83 Mirzo-Ulugbeka St, Tashkent, Uzbekistan, 100125

    E. M. Sultanova, M. Zh. Oripova, Yu. I. Oshchepkova & Sh. I. Salikhov

Authors
  1. E. M. Sultanova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Zh. Oripova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yu. I. Oshchepkova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sh. I. Salikhov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yu. I. Oshchepkova.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 54, No. 5, pp. 43 – 46, May, 2020.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sultanova, E.M., Oripova, M.Z., Oshchepkova, Y.I. et al. Chitosan-Based Hydrogel Composition with Megosine. Pharm Chem J 54, 514–517 (2020). https://doi.org/10.1007/s11094-020-02230-x

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-020-02230-x

Keywords

Search

Navigation