It is generally believed that large protein complexes provide a catalytic advantage due to substrate channeling between enzymatic domains. However, the structure and function of the pentafunctional AROM complex suggests a noteworthy exception.

中文翻译：

---

引导一个复杂的问题。

通常认为，由于酶域之间的底物通道，大蛋白质复合物提供催化优势。然而，五功能 AROM 复合体的结构和功能表明有一个值得注意的例外。