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ENZYMOLOGY

Channeling a complex question

Nature Chemical Biology volume 16, pages 935–937 (2020)Cite this article

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It is generally believed that large protein complexes provide a catalytic advantage due to substrate channeling between enzymatic domains. However, the structure and function of the pentafunctional AROM complex suggests a noteworthy exception.

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Fig. 1: The pentafunctional AROM complex does not channel substrates in vitro.

References

  1. Zhang, Y. H. Biotechnol. Adv. 29, 715–725 (2011).

    Article  CAS  Google Scholar 

  2. Hagel, J. M. & Facchini, P. J. J. Exp. Bot. 68, 4029–4043 (2017).

    Article  CAS  Google Scholar 

  3. Arora Verasztó, H. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-020-0587-9 (2020).

  4. Lumsden, J. & Coggins, J. R. Biochem. J. 161, 599–607 (1977).

    Article  CAS  Google Scholar 

  5. Richards, T. A. et al. Eukaryot. Cell 5, 1517–1531 (2006).

    Article  CAS  Google Scholar 

  6. Lamb, H. K., Bagshaw, C. R. & Hawkins, A. R. Mol. Gen. Genet. 227, 187–196 (1991).

    Article  CAS  Google Scholar 

  7. Sweetlove, L. J. & Fernie, A. R. Nat. Commun. 9, 2136 (2018).

    Article  Google Scholar 

  8. Kuzmak, A. et al. Sci. Rep. 9, 455 (2019).

    Article  Google Scholar 

Download references

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  1. Department of Biological Sciences, Marquette University, Milwaukee, WI, USA

    Martin St. Maurice

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  1. Martin St. Maurice
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Correspondence to Martin St. Maurice.

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St. Maurice, M. Channeling a complex question. Nat Chem Biol 16, 935–937 (2020). https://doi.org/10.1038/s41589-020-0619-5

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