Altered glycosylation helps cancer cells evade immune destruction, and targeted remodeling of glycans in vivo offers the ability to reprogram immune responses. A stable chemical linkage between an antibody and neuraminidase enables the targeted destruction of self-associated sialic acids to enhance antitumor immunity.

中文翻译：

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有针对性的自我毁灭。

糖基化的改变有助于癌细胞逃避免疫破坏，而体内聚糖的靶向重塑提供了重新编程免疫反应的能力。抗体和神经氨酸酶之间的稳定化学连接能够靶向破坏自身相关的唾液酸，从而增强抗肿瘤免疫力。