Altered glycosylation helps cancer cells evade immune destruction, and targeted remodeling of glycans in vivo offers the ability to reprogram immune responses. A stable chemical linkage between an antibody and neuraminidase enables the targeted destruction of self-associated sialic acids to enhance antitumor immunity.
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Rodrigues, E., Macauley, M.S. Targeted self-destruction. Nat Chem Biol 16, 1281–1283 (2020). https://doi.org/10.1038/s41589-020-0612-z
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DOI: https://doi.org/10.1038/s41589-020-0612-z
