Stroke is the fifth leading cause of death worldwide and is a main cause of disability in adults. Neither currently marketed drugs nor commonly used treatments can promote nerve repair and neurogenesis after stroke, and the repair of neurons damaged by ischemia has become a research focus. This article reviews several possible mechanisms of stroke and neurogenesis and introduces novel neurogenic agents (fibroblast growth factors, brain-derived neurotrophic factor, purine nucleosides, resveratrol, S-nitrosoglutathione, osteopontin, etc.) as well as other treatments that have shown neuroprotective or neurogenesis-promoting effects.

中文翻译：

---

脑缺血的神经发生的保护机制和治疗。

中风是全球第五大死亡原因，也是成年人残疾的主要原因。目前市售的药物和常用的治疗方法都不能促进中风后的神经修复和神经发生，并且缺血引起的神经元修复已成为研究的重点。本文回顾了中风和神经发生的几种可能机制，并介绍了新型的神经源性药物（成纤维细胞生长因子，脑源性神经营养因子，嘌呤核苷，白藜芦醇，S-亚硝基谷胱甘肽，骨桥蛋白等），以及其他显示出神经保护或神经保护作用的治疗方法。促进神经发生的作用。