Acute kidney injury (AKI) resulting from septic shock caused by sepsis is an important health problem encountered at rates of 55–73%. Increasing oxidative stress and inflammation following sepsis is a widely observed condition with rising mortality rates. The purpose of this study was to determine whether perindopril (PER) can prevent sepsis-associated AKI with its antioxidant, anti-inflammatory, and anti-apoptotic effects. The control group received an oral saline solution only for 4 days. Cecal ligation and puncture (CLP)–induced sepsis only was applied to the CLP group, while the CLP + PER (2 mg/kg) received CLP-induced sepsis together with 2 mg/kg PER via the oral route for 4 days before induction of sepsis. Finally, all rats were euthanized by anesthesia and sacrificed. TBARS, total SH levels and NF-κβ, TNF-α, and Caspase-3 expression were then calculated for statistical analysis. TBARS, total SH, NF-kβ/p65, TNF-a, and Caspase-3 levels increased in the CLP group. In contrast, oral administration of PER (2 mg/kg) to septic rats reduced TBARS levels and NF-kβ/p65, TNF-α, and Caspase-3 immunopositivity at biochemical analysis. PER treatment appears to be a promising method for preventing sepsis-induced acute kidney injury through its antioxidant anti-inflammation and anti-apoptotic activities.

由败血症引起的感染性休克导致的急性肾损伤 (AKI) 是一个重要的健康问题，发生率为 55-73%。脓毒症后氧化应激和炎症增加是一种广泛观察到的疾病，死亡率不断上升。本研究的目的是确定培哚普利 (PER) 是否可以通过其抗氧化、抗炎和抗凋亡作用预防败血症相关的 AKI。对照组仅接受口服生理盐水 4 天。盲肠结扎和穿刺（CLP）诱导的败血症仅应用于 CLP 组，而 CLP + PER（2 mg/kg）在诱导前通过口服途径接受 CLP 诱导的败血症和 2 mg/kg PER 4 天败血症。最后，将所有大鼠麻醉安乐死并处死。TBARS、总 SH 水平和 NF-κβ、TNF-α、然后计算 Caspase-3 表达进行统计分析。CLP 组的 TBARS、总 SH、NF-kβ/p65、TNF-a 和 Caspase-3 水平增加。相反，在生化分析中，向脓毒症大鼠口服 PER (2 mg/kg) 可降低 TBARS 水平和 NF-kβ/p65、TNF-α 和 Caspase-3 免疫阳性。PER 治疗似乎是通过其抗氧化抗炎和抗凋亡活性预防败血症引起的急性肾损伤的一种有前途的方法。