Mesenchymal stem cells (MSCs) hold enormous potential for the treatment of immune-related conditions and degenerative diseases, owing to their self-renewal and multilineage differentiation capabilities. Nevertheless, cellular senescence significantly impacts the quantity and quality of MSCs, limiting their clinical use. Mitochondria play essential roles in energy production by oxidative phosphorylation and metabolism of energy sources via the tricarboxylic acid cycle. Therefore, mitochondrial dysfunction is a primary cause of senescence in MSCs. Herein, we summarize the current knowledge regarding the mechanisms underlying mitochondrial dysfunction–associated cellular senescence. We also discuss potential methods to prevent or even reverse MSC senescence.

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线粒体功能障碍在间充质干细胞衰老中的作用

由于其自我更新和多向分化能力，间充质干细胞 (MSC) 在治疗免疫相关疾病和退行性疾病方面具有巨大潜力。然而，细胞衰老显着影响间充质干细胞的数量和质量，限制了它们的临床应用。线粒体在通过三羧酸循环的氧化磷酸化和能源代谢产生能量中发挥着重要作用。因此，线粒体功能障碍是 MSCs 衰老的主要原因。在此，我们总结了有关线粒体功能障碍相关细胞衰老潜在机制的当前知识。我们还讨论了预防甚至逆转 MSC 衰老的潜在方法。