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The role of mitochondrial dysfunction in mesenchymal stem cell senescence

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Abstract

Mesenchymal stem cells (MSCs) hold enormous potential for the treatment of immune-related conditions and degenerative diseases, owing to their self-renewal and multilineage differentiation capabilities. Nevertheless, cellular senescence significantly impacts the quantity and quality of MSCs, limiting their clinical use. Mitochondria play essential roles in energy production by oxidative phosphorylation and metabolism of energy sources via the tricarboxylic acid cycle. Therefore, mitochondrial dysfunction is a primary cause of senescence in MSCs. Herein, we summarize the current knowledge regarding the mechanisms underlying mitochondrial dysfunction–associated cellular senescence. We also discuss potential methods to prevent or even reverse MSC senescence.

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Funding

This work was financially supported by the National Natural Science Foundation of China (No. 81874007).

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Authors and Affiliations

  1. Department of Orthopedics, The Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88, Jiefang Road, Hangzhou, 310009, China

    Yibo Wang, Yunlong Liu, Erman Chen & Zhijun Pan

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  1. Yibo Wang
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  2. Yunlong Liu
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Correspondence to Zhijun Pan.

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Wang, Y., Liu, Y., Chen, E. et al. The role of mitochondrial dysfunction in mesenchymal stem cell senescence. Cell Tissue Res 382, 457–462 (2020). https://doi.org/10.1007/s00441-020-03272-z

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