The carp edema virus (CEV) is a pox virus that infects common carp and koi. Its infection causes koi sleepy disease (KSD) that is one of the most important common carp diseases with considerable risk to the productivity of common carp and koi all over the world. In 1970s, KSD was first time reported in Japan but recent increase in worldwide trade of the common carp is causing the spread of virus to various other countries and it is becoming a major threat to the common carp and koi industries. Previous research revealed that the CEV usually required suitable water temperature between 20 and 25 °C and disease outbreaks mostly occur in months of June and July in reported countries. At present, no suitable cell line has been reported for the in vitro replication of CEV; thus, it is difficult to study the CEV in vitro. This review is aimed to summarize the current findings on the known characterization of CEV, KSD pathogenesis, disease diagnostic techniques, its control, and preventive measures. The future prospective about CEV research and development is also discussed in this review.

鲤鱼水肿病毒（CEV）是一种痘病毒，可感染普通鲤鱼和锦鲤。它的感染导致锦鲤嗜睡病（KSD），它是最重要的鲤鱼常见疾病之一，对全世界鲤鱼和锦鲤的生产具有相当大的风险。1970年代，KSD在日本首次被报道，但是最近鲤鱼的全球贸易增加正在引起病毒向其他国家的传播，并且正成为鲤鱼和锦鲤产业的主要威胁。先前的研究表明，CEV通常需要在20至25°C之间的合适水温，在报告的国家中，疾病暴发大多发生在6月和7月。目前，尚无合适的细胞株可用于CEV的体外复制。因此，很难在体外研究CEV。这篇综述旨在总结有关CEV，KSD发病机理，疾病诊断技术，其控制和预防措施的已知特征的最新发现。本文还将讨论有关CEV研究与开发的未来前景。