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Current findings on carp edema virus, control challenges, and future outlook

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Abstract

The carp edema virus (CEV) is a pox virus that infects common carp and koi. Its infection causes koi sleepy disease (KSD) that is one of the most important common carp diseases with considerable risk to the productivity of common carp and koi all over the world. In 1970s, KSD was first time reported in Japan but recent increase in worldwide trade of the common carp is causing the spread of virus to various other countries and it is becoming a major threat to the common carp and koi industries. Previous research revealed that the CEV usually required suitable water temperature between 20 and 25 °C and disease outbreaks mostly occur in months of June and July in reported countries. At present, no suitable cell line has been reported for the in vitro replication of CEV; thus, it is difficult to study the CEV in vitro. This review is aimed to summarize the current findings on the known characterization of CEV, KSD pathogenesis, disease diagnostic techniques, its control, and preventive measures. The future prospective about CEV research and development is also discussed in this review.

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Funding

This study was supported by a project funded by Sichuan overseas student’s science and technology activities project merit funding and the Sichuan Agricultural University Shuangzhi Support Planning (grant number 03571815 and 03572452).

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Author notes

  1. Tayyab Rehman and Lizi Yin contributed equally to this work.

Authors and Affiliations

  1. Department of Basic Veterinary, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China

    Tayyab Rehman, Lizi Yin, Yaojia Zhou, Kaiyu Wang, Yi Geng, Jing Fang, Zhengli Chen, Hongrui Guo, Weiming Lai & Ping Ouyang

  2. Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA

    Muhammad Bilal Latif

  3. Department of Aquaculture, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China

    Xiaoli Huang & Defang Chen

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  1. Tayyab Rehman
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  2. Lizi Yin
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  3. Muhammad Bilal Latif
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Contributions

TR and LZY wrote and designed the manuscript. MBL, YJZ, PO, XLH, DFC, JF, ZLC, HRG, and WML contributed through their intellectual inputs. KYW, YG, and PO read and corrected the contents.

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Correspondence to Ping Ouyang.

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Rehman, T., Yin, L., Latif, M.B. et al. Current findings on carp edema virus, control challenges, and future outlook. Aquacult Int 28, 2015–2026 (2020). https://doi.org/10.1007/s10499-020-00573-6

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