Abstract

The sciatic nerve injury is accompanied by the activation of inflammatory processes in nerve fibers and the spinal cord lumbar segment, contributing to the development of neuropathic pain syndrome. In our study, ligation and transection of the sciatic nerve lead to a local inflammatory response, expressed in swelling and damage to nerve fibers and impaired innervation of peripheral tissues. At the same time, there is an increase in micro- and astroglial activity in the ventrolateral nucleus of the spinal cord lumbar segment (L4–L6), while motor neurons are encapsulated by microglia cells. At the same time, neurodegeneration of motor neurons is observed only during transection of the sciatic nerve. Thus, the results of this study indicate the active participation of the spinal cord motor nerve cells in the pathophysiological process after sciatic nerve injury.

中文翻译：

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大鼠脊髓前外侧核坐骨神经损伤中的微和星形胶质细胞活性。

摘要

坐骨神经损伤伴随着神经纤维和脊髓腰段中炎症过程的激活，从而导致神经性疼痛综合征的发展。在我们的研究中，坐骨神经的结扎和横断导致局部炎症反应，表现为神经纤维的肿胀和损伤以及周围组织的神经支配受损。同时，脊髓腰段（L4–L6）的腹外侧核中的微星形胶质活动增加，而运动神经元被小胶质细胞包裹。同时，仅在坐骨神经横切期间观察到运动神经元的神经变性。从而，