A novel luminescent coordination polymer (CP) based on Zn(II) ions as nodes [Zn(OPY)_1.5(Hbtc)]_n (1), [H₃btc = trimesic acid and OPY = 4,4′-(oxybis(4,1-phenylene))dipyridine] has been prepared via the solvothermal assembly of a tripodal multicarboxylic acid ligand, a bis-pyridyl ligand with V-shape containing two diverse coordination patterns as well as Zn^{2 +} ion. The experiments of photoluminescence also reflect that the coordination polymer 1 has high sensitivity to potassium dichromate, and its quenching efficiency is K_sv of 2.12 × 10⁴ L·mol^− 1. Furthermore, its treatment activity on orthodontic root absorption was evaluated in vivo. Firstly, the CCK-8 assay was performed in this research to evaluate the biotoxicity of the synthetic compound. Next, the TNF-α and Cbfα1 released by the periodontal ligament fibroblast was determined via the ELISA test kit. In addition to this, the signaling pathway of NF-κB activation after treated with compound was measured by the RT-PCR.

中文翻译：

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一种新的发光 Zn(II) 配合物：通过抑制炎症反应对 Cr2O72- 的选择性感应和对正畸牙根吸收的预防活性。

基于 Zn(II) 离子作为节点的新型发光配位聚合物 (CP) [Zn(OPY) _1.5 (Hbtc)] _n ( 1 ), [H ₃ btc = 均苯三甲酸和 OPY = 4,4'-(oxybis( 4,1-phenylene))dipyridine]通过溶剂热组装三足多羧酸配体、具有两种不同配位模式的V形双吡啶配体以及Zn 2 + 离子^制备。光致发光实验也反映出配位聚合物1对重铬酸钾具有较高的敏感性，其猝灭效率为K _sv 2.12 × 10 ⁴  L · mol ^{− 1}. 此外，在体内评估了其对正畸牙根吸收的治疗活性。首先，在本研究中进行了 CCK-8 测定，以评估合成化合物的生物毒性。接下来，通过ELISA检测试剂盒测定牙周膜成纤维细胞释放的TNF-α和Cbfα1。除此之外，通过RT-PCR测量用化合物处理后NF-κB活化的信号通路。