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The progression of serum cystatin C concentrations within the first month of life after preterm birth-a worldwide systematic review.
Pediatric Nephrology ( IF 2.6 ) Pub Date : 2020-08-05 , DOI: 10.1007/s00467-020-04543-1
Anjana Renganathan 1, 2 , Barbara B Warner 3 , Phillip I Tarr 4, 5 , Vikas R Dharnidharka 1
Affiliation  

Multiple single-center studies have examined the progression of kidney function biomarkers such as serum cystatin C (Cys C) in the first 30 days of life (DOL) after preterm birth, but from different ethnicities and in different gestational ages (GA), without a functional summary available. We performed a systematic literature review within PubMed, Google Scholar, and Scopus, with additional use of the snowballing method to find studies including data on serum Cys C concentrations in the first 30 DOL. We identified 15 papers that met criteria, published from 2000 to 2019, from 10 countries across 4 continents, in 1468 babies born preterm. Cys C was superior to creatinine in 11/13 studies, and equal in 2/13. For infants born at 24-28 weeks GA, the DOL1 Cys C concentrations ranged from 1.44 to 1.90 mg/L, from 1.20 to 1.77 on DOL3, and from 1.36 to 2.02 between DOL 4 and 30. For infants born at 29-33 weeks GA, the DOL1 Cys C values ranged from 1.41 to 1.96 mg/L, from 1.28 to 1.70 on DOL3, and 1.51 to 1.87 between DOL 4 and 30. For preterm infants born after 34 weeks GA, the DOL1 Cys C values ranged from 1.22 to 1.96 mg/L, from 1.24 to 1.85 on DOL3, and 1.22 to 1.82 between DOL 4 and 30. This systematic review provides generalizable worldwide reference data on Cys C that could be used to estimate progression or resolution of abnormal kidney function in the first months after preterm birth, stratified by GA.

中文翻译:

早产后第一个月内血清胱抑素 C 浓度的进展——一项全球系统评价。

多项单中心研究检查了早产后生命的前 30 天 (DOL) 中肾功能生物标志物如血清胱抑素 C (Cys C) 的进展,但来自不同种族和不同胎龄 (GA),没有可用的功能摘要。我们在 PubMed、Google Scholar 和 Scopus 中进行了系统的文献回顾,另外使用滚雪球方法来查找研究,包括前 30 个 DOL 中血清 Cys C 浓度的数据。我们确定了 15 篇符合标准的论文,发表于 2000 年至 2019 年,来自四大洲的 10 个国家,涉及 1468 名早产婴儿。在 11/13 的研究中,Cys C 优于肌酐,在 2/13 中相等。对于 GA 24-28 周出生的婴儿,DOL1 Cys C 浓度范围为 1.44 至 1.90 mg/L,DOL3 为 1.20 至 1.77,以及 1.36 至 2。
更新日期:2020-08-05
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