Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that is commonly used as an anti-inflammatory, anti-pyretic, and analgesic. Although some studies have focused on the anti-inflammatory and anti-pyretic properties of ibuprofen during febrile convulsions, only one has investigated its antiepileptic effects. In the present study, we aimed to investigate the effects of ibuprofen in rats exposed to pentylenetetrazol (PTZ)-induced seizures. In total, 48 rats were randomly divided in two groups: Group A for electroencephalography (EEG) recordings and Group B for behavioral assessment. All EEG recordings and behavioral assessment protocols were performed. In addition, groups were compared in terms of prostaglandin F2 alfa (PGF2α) levels in the brain. We demonstrated the beneficial effects of the administration of ibuprofen in PTZ-induced seizures in rats via the following findings: spike percentages and Racine convulsion scale values were significantly lower and first myoclonic jerk (FMJ) onset times were significantly higher in the ibuprofen-administered groups. Moreover, PGF2α levels in the brain were significantly higher in the saline and PTZ 70 mg/kg group than in the control and PTZ 70 mg/kg and 400 mg/kg ibuprofen groups. Our study is the first to demonstrate the beneficial effects of ibuprofen on seizures through behavioral, EEG, and PGF2α brain assessments. Ibuprofen can be used for epilepsy and febrile seizures safely and without inducing seizures. However, further experimental and clinical studies are needed to confirm our results.

布洛芬是一种非甾体类抗炎药（NSAID），通常用作抗炎，解热和镇痛药。尽管一些研究集中于布洛芬在高热惊厥过程中的抗炎和退热作用，但只有一项研究了其抗癫痫作用。在本研究中，我们旨在研究布洛芬对戊四氮（PTZ）诱发的癫痫发作大鼠的影响。总共48只大鼠随机分为两组：A组用于脑电图（EEG）记录，B组用于行为评估。进行所有脑电图记录和行为评估方案。此外，根据脑中前列腺素F2α（PGF2α）水平对各组进行了比较。我们通过以下发现证明了布洛芬对PTZ诱发的大鼠癫痫发作的有益作用：布洛芬给药组的刺突率和Racine抽搐量值显着降低，首次阵发性抽搐（FMJ）发作时间明显更长。此外，生理盐水和PTZ 70 mg / kg组的大脑中PGF2α水平显着高于对照组以及PTZ 70 mg / kg和400 mg / kg布洛芬组。我们的研究首次通过行为，脑电图和PGF2α脑评估证明了布洛芬对癫痫发作的有益作用。布洛芬可安全用于癫痫和高热惊厥，而不会引起惊厥。但是，需要进一步的实验和临床研究来证实我们的结果。在布洛芬给药组中，刺突率和Racine惊厥量表值显着降低，首次肌阵挛性抽搐（FMJ）发作时间显着更长。此外，生理盐水和PTZ 70 mg / kg组的大脑中PGF2α水平显着高于对照组以及PTZ 70 mg / kg和400 mg / kg布洛芬组。我们的研究首次通过行为，脑电图和PGF2α脑评估证明了布洛芬对癫痫发作的有益作用。布洛芬可安全用于癫痫和高热惊厥，而不会引起惊厥。但是，需要进一步的实验和临床研究来证实我们的结果。在布洛芬给药组中，刺突率和Racine惊厥量表值显着降低，首次肌阵挛性抽搐（FMJ）发作时间显着更长。此外，生理盐水和PTZ 70 mg / kg组的大脑中PGF2α水平显着高于对照组以及PTZ 70 mg / kg和400 mg / kg布洛芬组。我们的研究首次通过行为，脑电图和PGF2α脑评估证明了布洛芬对癫痫发作的有益作用。布洛芬可安全用于癫痫和高热惊厥，而不会引起惊厥。但是，需要进一步的实验和临床研究来证实我们的结果。生理盐水和PTZ 70 mg / kg组的大脑中PGF2α水平显着高于对照组和PTZ 70 mg / kg和400 mg / kg布洛芬组。我们的研究首次通过行为，脑电图和PGF2α脑评估证明了布洛芬对癫痫发作的有益作用。布洛芬可安全用于癫痫和高热惊厥，而不会引起惊厥。但是，需要进一步的实验和临床研究来证实我们的结果。生理盐水和PTZ 70 mg / kg组的大脑中PGF2α水平显着高于对照组和PTZ 70 mg / kg和400 mg / kg布洛芬组。我们的研究首次通过行为，脑电图和PGF2α脑评估证明了布洛芬对癫痫发作的有益作用。布洛芬可安全用于癫痫和高热惊厥，而不会引起惊厥。但是，需要进一步的实验和临床研究来证实我们的结果。布洛芬可安全用于癫痫和高热惊厥，而不会引起惊厥。但是，需要进一步的实验和临床研究来证实我们的结果。布洛芬可安全用于癫痫和高热惊厥，而不会引起惊厥。但是，需要进一步的实验和临床研究来证实我们的结果。