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Beneficial Effects of Ibuprofen on Pentylenetetrazol-induced Convulsion

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Abstract

Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that is commonly used as an anti-inflammatory, anti-pyretic, and analgesic. Although some studies have focused on the anti-inflammatory and anti-pyretic properties of ibuprofen during febrile convulsions, only one has investigated its antiepileptic effects. In the present study, we aimed to investigate the effects of ibuprofen in rats exposed to pentylenetetrazol (PTZ)-induced seizures. In total, 48 rats were randomly divided in two groups: Group A for electroencephalography (EEG) recordings and Group B for behavioral assessment. All EEG recordings and behavioral assessment protocols were performed. In addition, groups were compared in terms of prostaglandin F2 alfa (PGF2α) levels in the brain. We demonstrated the beneficial effects of the administration of ibuprofen in PTZ-induced seizures in rats via the following findings: spike percentages and Racine convulsion scale values were significantly lower and first myoclonic jerk (FMJ) onset times were significantly higher in the ibuprofen-administered groups. Moreover, PGF2α levels in the brain were significantly higher in the saline and PTZ 70 mg/kg group than in the control and PTZ 70 mg/kg and 400 mg/kg ibuprofen groups. Our study is the first to demonstrate the beneficial effects of ibuprofen on seizures through behavioral, EEG, and PGF2α brain assessments. Ibuprofen can be used for epilepsy and febrile seizures safely and without inducing seizures. However, further experimental and clinical studies are needed to confirm our results.

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Authors and Affiliations

  1. Department of Pediatrics, Istanbul Medeniyet University, Göztepe Eğitim ve Araştırma Hastanesi, Göztepe, İstanbul, 34190, Turkey

    Ferit Durankuş & Evrim Şenkal

  2. Istanbul Training and Education Hospital, Department of Pediatrics, İstanbul, Turkey

    Eda Sünnetçi

  3. Faculty of Medicine, Department of Psychiatry and Behavioural Neuroscience, Tekirdağ Namık Kemal University, Tekirdağ, Turkey

    Yakup Albayrak & Murat Beyazyüz

  4. Department of Radiation Oncolgy, Kartal Education and Research Hospital, İstanbul, Turkey

    Özüm Atasoy

  5. Department of Physiology, Demiroğlu Bilim University Medical School, İstanbul, Turkey

    Oytun Erbaş

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  1. Ferit Durankuş
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Correspondence to Ferit Durankuş.

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The experimental procedures employed in the present study were approved by the Animal Ethics Committee (51879863-59a). Present manuscript was approved by Local Institutional Animal Care and Ethics Committee.

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Durankuş, F., Şenkal, E., Sünnetçi, E. et al. Beneficial Effects of Ibuprofen on Pentylenetetrazol-induced Convulsion. Neurochem Res 45, 2409–2416 (2020). https://doi.org/10.1007/s11064-020-03101-3

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