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From Input to Output: The Lap/c-di-GMP Biofilm Regulatory Circuit.
Annual Review of Microbiology ( IF 8.5 ) Pub Date : 2020-09-09 , DOI: 10.1146/annurev-micro-011520-094214
Alan J Collins 1, 2 , T Jarrod Smith 2, 3 , Holger Sondermann 4 , George A O'Toole 2
Affiliation  

Biofilms are the dominant bacterial lifestyle. The regulation of the formation and dispersal of bacterial biofilms has been the subject of study in many organisms. Over the last two decades, the mechanisms of Pseudomonas fluorescens biofilm formation and regulation have emerged as among the best understood of any bacterial biofilm system. Biofilm formation by P. fluorescens occurs through the localization of an adhesin, LapA, to the outer membrane via a variant of the classical type I secretion system. The decision between biofilm formation and dispersal is mediated by LapD, a c-di-GMP receptor, and LapG, a periplasmic protease, which together control whether LapA is retained or released from the cell surface. LapA localization is also controlled by a complex network of c-di-GMP-metabolizing enzymes. This review describes the current understanding of LapA-mediated biofilm formation by P. fluorescens and discusses several emerging models for the regulation and function of this adhesin.

中文翻译:


从输入到输出:Lap/c-di-GMP 生物膜调节电路。

生物膜是主要的细菌生活方式。细菌生物膜的形成和扩散的调节一直是许多生物体研究的主题。在过去的二十年里,荧光假单胞菌生物膜的形成和调控机制已成为对任何细菌生物膜系统的最了解的机制之一。荧光假单胞菌形成的生物膜通过经典 I 型分泌系统的变体将粘附素 LapA 定位到外膜而发生。生物膜形成和扩散之间的决定由 LapD(一种 c-di-GMP 受体)和 LapG(一种周质蛋白酶)介导,它们共同控制 LapA 是保留还是从细胞表面释放。LapA 定位也由复杂的 c-di-GMP 代谢酶网络控制。这篇综述描述了目前对荧光假单胞菌 LapA 介导的生物膜形成的理解,并讨论了这种粘附素的调节和功能的几种新兴模型。

更新日期:2020-09-10
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