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Annual Review of Microbiology

Volume 74, 2020

From Input to Output: The Lap/c-di-GMP Biofilm Regulatory Circuit

Abstract

Biofilms are the dominant bacterial lifestyle. The regulation of the formation and dispersal of bacterial biofilms has been the subject of study in many organisms. Over the last two decades, the mechanisms of biofilm formation and regulation have emerged as among the best understood of any bacterial biofilm system. Biofilm formation by occurs through the localization of an adhesin, LapA, to the outer membrane via a variant of the classical type I secretion system. The decision between biofilm formation and dispersal is mediated by LapD, a c-di-GMP receptor, and LapG, a periplasmic protease, which together control whether LapA is retained or released from the cell surface. LapA localization is also controlled by a complex network of c-di-GMP-metabolizing enzymes. This review describes the current understanding of LapA-mediated biofilm formation by and discusses several emerging models for the regulation and function of this adhesin.

Keyword(s): biofilm, c-di-GMP, LapA, Pseudomonas, signal transduction, type I secretion
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/content/journals/10.1146/annurev-micro-011520-094214
2020-09-08
2024-04-24
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/content/journals/10.1146/annurev-micro-011520-094214
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From Input to Output: The Lap/c-di-GMP Biofilm Regulatory Circuit
Annual Review of Microbiology 74, 607 (2020); https://doi.org/10.1146/annurev-micro-011520-094214
/content/journals/10.1146/annurev-micro-011520-094214
/content/journals/10.1146/annurev-micro-011520-094214
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