As a bone scaffold, meeting all basic requirements besides dealing with other bone-related issues—bone cancer and accelerated regeneration—is not expected from traditional scaffolds, but a newer class of scaffolds called multifunctional. From a clinical point of view, being a multifunctional scaffold means reducing in healing time, direct costs—medicine, surgery, and hospitalization—and indirect costs—loss of mobility, losing job, and pain. The main aim of the present review is following the multifunctional bone scaffolds trend to deal with both bone regeneration and cancer therapy. Special consideration is given to different fabrication techniques which have been applied to yield these materials spanning from traditional to modern ones. Moreover, the hierarchical structure of bone plus bone cancers and available medicines to them are introduced to familiarize the potential reader of review with the pluri-disciplinary essence of the field. Eventually, a brief discussion relating to the future trend of these materials is provided.

中文翻译：

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从传统技术到现代技术的多功能骨支架的历程

作为骨骼支架，除了传统骨骼支架外，还不能满足除骨骼相关问题（骨癌和加速再生）以外的所有基本要求，而是一种新型的多功能支架。从临床角度来看，成为多功能支架意味着减少愈合时间，减少直接成本（医药，手术和住院）以及间接成本（丧失活动能力，失去工作和痛苦）。本综述的主要目的是遵循多功能骨支架趋势来处理骨再生和癌症治疗。特别考虑了已应用于生产从传统材料到现代材料的这些材料的不同制造技术。此外，介绍了骨加骨癌的层次结构和可用的药物，以使潜在的阅读读者熟悉该领域的多学科本质。最终，提供了有关这些材料的未来趋势的简短讨论。