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The journey of multifunctional bone scaffolds fabricated from traditional toward modern techniques

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Abstract

As a bone scaffold, meeting all basic requirements besides dealing with other bone-related issues—bone cancer and accelerated regeneration—is not expected from traditional scaffolds, but a newer class of scaffolds called multifunctional. From a clinical point of view, being a multifunctional scaffold means reducing in healing time, direct costs—medicine, surgery, and hospitalization—and indirect costs—loss of mobility, losing job, and pain. The main aim of the present review is following the multifunctional bone scaffolds trend to deal with both bone regeneration and cancer therapy. Special consideration is given to different fabrication techniques which have been applied to yield these materials spanning from traditional to modern ones. Moreover, the hierarchical structure of bone plus bone cancers and available medicines to them are introduced to familiarize the potential reader of review with the pluri-disciplinary essence of the field. Eventually, a brief discussion relating to the future trend of these materials is provided.

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Authors and Affiliations

  1. Department of Biomaterials, Tissue Engineering and Nanotechnology, School of Advanced Technologies in Medicine (ATiM), Isfahan University of Medical Sciences, Isfahan, Iran

    Ashkan Bigham

  2. Department of Materials Science and Engineering, Faculty of Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore, 117576, Singapore

    Firoozeh Foroughi

  3. Department of Mechanical Engineering, Center for Nanofibers and Nanotechnology, National University of Singapore, Singapore, 119260, Singapore

    Erfan Rezvani Ghomi & Seeram Ramakrishna

  4. Biosensor Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

    Mohammad Rafienia

  5. Department of Materials and Polymer Engineering, Faculty of Engineering, Hakim Sabzevari University, 9617976487, Sabzevar, Iran

    Rasoul Esmaeely Neisiany

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AB, FF, and ERG summarized the literature and wrote a major part of the manuscript. MR, REN, and SR conducted the deep review, editing, guidance, and supervision. All authors have read and approved the article for publication.

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Bigham, A., Foroughi, F., Rezvani Ghomi, E. et al. The journey of multifunctional bone scaffolds fabricated from traditional toward modern techniques. Bio-des. Manuf. 3, 281–306 (2020). https://doi.org/10.1007/s42242-020-00094-4

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