Skin consists of the epidermis and dermis, which are connected by a specialized basement membrane—the epidermal basement membrane. Both the epidermal basement membrane and the underlying interstitial extracellular matrix (ECM) created by dermal fibroblasts contain distinct network-forming macromolecules. These matrices play various roles in order to maintain skin homeostasis and integrity. Within this complex interplay of cells and matrices, cell surface receptors play essential roles not only for inside-out and outside-in signaling, but also for establishing mechanical and biochemical properties of skin. Already minor modulations of this multifactorial cross-talk can lead to severe and systemic diseases. In this review, major epidermal and dermal cell surface receptors will be addressed with respect to their interactions with matrix components as well as their roles in fibrotic, inflammatory or tumorigenic skin diseases.

中文翻译：

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皮肤细胞表面受体和细胞外基质之间的相互作用。


皮肤由表皮和真皮组成，它们通过特殊的基底膜——表皮基底膜连接。表皮基底膜和由真皮成纤维细胞产生的下面的间质细胞外基质（ECM）都含有不同的网络形成大分子。这些基质发挥着各种作用，以维持皮肤稳态和完整性。在细胞和基质的这种复杂的相互作用中，细胞表面受体不仅对于由内而外和由外向内的信号传导发挥着重要作用，而且对于建立皮肤的机械和生化特性也发挥着重要作用。这种多因素相互作用的微小调节就可能导致严重的全身性疾病。在这篇综述中，将讨论主要的表皮和真皮细胞表面受体与基质成分的相互作用以及它们在纤维化、炎症或致瘤性皮肤病中的作用。