The transdermal drug delivery approach has been considered a potential therapy for human hypertrophic scars (HSs) instead of current uncomfortable surgical excision, local injection and laser therapy. However, a facile and efficient drug delivery method is urgently needed to overcome the skin barrier of transdermal administration. Herein, we employed a DNA-Fe nanoparticle delivery system via Fe ion driven self-assembly to satisfy the requirement of transdermal administration for HS therapy. Doxorubicin hydrochloride (DOX) as one of the widely used anticancer drugs was employed to treat the hyperplasia of abnormal skin fibrous tissue. Both in vitro and in vivo experiments of the DOX loaded DNA-Fe nanoparticles (DOX@DNA-Fe NPs) were performed to demonstrate the penetration ability, rapid drug release, and scar-inhibiting effects. This facile and efficient approach for HS therapy via a DNA-based transdermal drug delivery system may provide more possibilities for the development of transdermal administration.

中文翻译：

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通过基于DNA的透皮药物递送进行肥厚性瘢痕治疗的简便有效方法。

经皮给药方法已被认为是治疗人类肥厚性瘢痕（HSs）的一种潜在疗法，而不是目前不舒服的手术切除，局部注射和激光疗法。然而，迫切需要一种简便而有效的药物递送方法来克服经皮给药的皮肤屏障。在本文中，我们通过Fe离子驱动的自组装技术采用了DNA-Fe纳米颗粒递送系统，以满足HS治疗的透皮给药要求。盐酸阿霉素（DOX）作为一种广泛使用的抗癌药物被用于治疗异常皮肤纤维组织的增生。二者在体外和体内对载有DOX的DNA-Fe纳米颗粒（DOX @ DNA-Fe NPs）进行了实验，以证明其渗透能力，快速药物释放和抑制疤痕的作用。通过基于DNA的透皮给药系统进行HS治疗的这种简便有效的方法可能为开发透皮给药提供更多可能性。