A facile and efficient approach for hypertrophic scar therapy via DNA-based transdermal drug delivery

Kai Jiang; Yunsheng Chen; Di Zhao; Jin Cheng; Fangli Mo; Bin Ji; Chao Gao; Chuan Zhang; Jie Song

doi:10.1039/D0NR04751A

A facile and efficient approach for hypertrophic scar therapy via DNA-based transdermal drug delivery†

Kai Jiang,^a Yunsheng Chen,^b Di Zhao,^a Jin Cheng,^a Fangli Mo,^a Bin Ji,^a Chao Gao,^a Chuan Zhang

^c and Jie Song

*^ad

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* Corresponding authors

^a Institute of Nano Biomedicine and Engineering, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China
E-mail: J.S.sjie@sjtu.edu.cn

^b Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, 639 Zhizaoju Rd, Shanghai 200011, People's Republic of China

^c School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, People's Republic of China

^d Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences; The Cancer Hospital of the University of Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, People's Republic of China

Abstract

The transdermal drug delivery approach has been considered a potential therapy for human hypertrophic scars (HSs) instead of current uncomfortable surgical excision, local injection and laser therapy. However, a facile and efficient drug delivery method is urgently needed to overcome the skin barrier of transdermal administration. Herein, we employed a DNA-Fe nanoparticle delivery system via Fe ion driven self-assembly to satisfy the requirement of transdermal administration for HS therapy. Doxorubicin hydrochloride (DOX) as one of the widely used anticancer drugs was employed to treat the hyperplasia of abnormal skin fibrous tissue. Both in vitro and in vivo experiments of the DOX loaded DNA-Fe nanoparticles (DOX@DNA-Fe NPs) were performed to demonstrate the penetration ability, rapid drug release, and scar-inhibiting effects. This facile and efficient approach for HS therapy via a DNA-based transdermal drug delivery system may provide more possibilities for the development of transdermal administration.

This article is part of the themed collection: 2020 Nanoscale HOT Article Collection

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DOI: https://doi.org/10.1039/D0NR04751A
Article type: Paper
Submitted: 23 Jun 2020
Accepted: 07 Aug 2020
First published: 10 Aug 2020

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Nanoscale, 2020,12, 18682-18691

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A facile and efficient approach for hypertrophic scar therapy via DNA-based transdermal drug delivery

K. Jiang, Y. Chen, D. Zhao, J. Cheng, F. Mo, B. Ji, C. Gao, C. Zhang and J. Song, Nanoscale, 2020, 12, 18682 DOI: 10.1039/D0NR04751A

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A facile and efficient approach for hypertrophic scar therapy via DNA-based transdermal drug delivery†

Abstract

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A facile and efficient approach for hypertrophic scar therapy via DNA-based transdermal drug delivery

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