Hydrogel-based nonviral gene delivery constitutes a powerful strategy in various regenerative medicine scenarios, as those concerning the treatment of musculoskeletal, cardiovascular, or neural tissues disorders as well as wound healing. By a minimally invasive administration, these systems can provide a spatially and temporarily defined supply of specific gene sequences into the target tissue cells that are overexpressing or silencing the original gene, which can promote natural repairing mechanisms to achieve the desired effect. In the present work, we provide an overview of the most avant-garde approaches using various hydrogels systems for controlled delivery of therapeutic nucleic acid molecules in different regenerative medicine approaches.

中文翻译：

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再生医学方法中基于水凝胶的局部非病毒基因传递——概述。


基于水凝胶的非病毒基因传递在各种再生医学场景中构成了一种强大的策略，例如涉及肌肉骨骼、心血管或神经组织疾病以及伤口愈合的治疗。通过微创给药，这些系统可以向过度表达或沉默原始基因的靶组织细胞中提供空间和临时限定的特定基因序列，从而促进自然修复机制以达到预期效果。在目前的工作中，我们概述了使用各种水凝胶系统在不同再生医学方法中控制递送治疗性核酸分子的最前卫方法。