The explosive spread of SARS-CoV-2 suggests that a vaccine will be required to end this global pandemic. Progress in SARS-CoV-2 vaccine development to date has been faster than for any other pathogen in history. Multiple SARS-CoV-2 vaccine candidates have been evaluated in preclinical models and are currently in clinical trials. In this Perspective, we discuss three topics that are critical for SARS-CoV-2 vaccine development: antigen selection and engineering, preclinical challenge studies in non-human primate models, and immune correlates of protection.

中文翻译：

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SARS-CoV-2 疫苗开发的方法和挑战。

SARS-CoV-2 的爆炸性传播表明需要疫苗来结束这场全球大流行。迄今为止，SARS-CoV-2 疫苗的开发进展比历史上任何其他病原体都要快。多种 SARS-CoV-2 候选疫苗已在临床前模型中进行了评估，目前正在进行临床试验。在本视角中，我们讨论了对于 SARS-CoV-2 疫苗开发至关重要的三个主题：抗原选择和工程、非人类灵长类动物模型的临床前挑战研究以及保护的免疫相关性。