Cell Host & Microbe
Volume 28, Issue 3, 9 September 2020, Pages 364-370
Journal home page for Cell Host & Microbe

Perspective
Approaches and Challenges in SARS-CoV-2 Vaccine Development

https://doi.org/10.1016/j.chom.2020.08.002Get rights and content
Under an Elsevier user license
open archive

Summary

The explosive spread of SARS-CoV-2 suggests that a vaccine will be required to end this global pandemic. Progress in SARS-CoV-2 vaccine development to date has been faster than for any other pathogen in history. Multiple SARS-CoV-2 vaccine candidates have been evaluated in preclinical models and are currently in clinical trials. In this Perspective, we discuss three topics that are critical for SARS-CoV-2 vaccine development: antigen selection and engineering, preclinical challenge studies in non-human primate models, and immune correlates of protection.

Keywords

SARS-CoV-2
COVID-19
vaccine

Cited by (0)

5

These authors contributed equally to this work