The transformative effect of oxygen on conventional x-ray radiotherapy has long been known, with the presence of molecular oxygen boosting treatment efficacy multi-fold. This effect is present too in charged particle therapy, but the boosting potential decreases with increasing linear energy transfer of the incident radiation. With particle modalities such as proton therapy becoming common-place and emerging technologies like carbon-ion therapy on the horizon, it is pertinent to address the additive dose boost gained from molecular oxygen with high energy radiation, and the implications of this for dose planning. This work establishes an empirical model for oxygen enhancement across the radiotherapy energy spectrum, and discusses implications of this for therapy.

中文翻译：

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估计带电粒子辐射的氧气增强比

氧对常规X射线放射疗法的转化作用早已为人所知，而分子氧促进治疗的功效是多重的。该效应在带电粒子疗法中也存在，但随着入射辐射的线性能量传递增加，增强电位降低。随着质子治疗等粒子模式变得司空见惯，以及碳离子治疗等新兴技术的出现，有必要解决分子氧在高能辐射下获得的附加剂量增加及其对剂量计划的影响。这项工作建立了放疗能谱范围内氧气增强的经验模型，并讨论了其对治疗的意义。