Combining synthetic polymer scaffolds with inorganic bioactive factors is widely used to promote the bioactivity and bone conductivity of bone tissue. However, except for the chemical composition of scaffold, the biomimetic structure also plays an important role in its application. In this study, we report the fabrication of polylactic acid/hydroxyapatite (PLA/HA) composite nanofibrous scaffolds via phase separation method to mimic the native extracellular matrix (ECM). The SEM analysis showed that the addition of HA dramatically impacted the morphology of the PLA matrix, which changed from 3D nanofibrous network structure to a disorderly micro-nanofibrous porous structure. At the same time, HA particles could be evenly dispersed at the end of the fiber. The FTIR and XRD demonstrated that there was not any chemical interaction between PLA and HA. Thermal analyses showed that HA could decrease the crystallization of PLA, but improve the thermal decomposition temperature of the composite scaffold. Moreover, water contact angle analysis of the PLA/HA composite scaffold demonstrated that the hydrophilicity increased with the addition of HA. Furthermore, apatite-formation ability tests confirmed that HA could not only more and faster induced the deposition of weak hydroxyapatite but also induced specific morphology of HA.

合成聚合物支架与无机生物活性因子的组合被广泛用于促进骨组织的生物活性和骨传导性。但是，除了脚手架的化学成分外，仿生结构在其应用中也起着重要作用。在这项研究中，我们报告了通过相分离法模拟天然细胞外基质（ECM）制备聚乳酸/羟基磷灰石（PLA / HA）复合纳米纤维支架。SEM分析表明，HA的添加极大地影响了PLA基质的形态，从3D纳米纤维网络结构变为无序的微纳米纤维多孔结构。同时，HA颗粒可以均匀地分散在纤维的末端。FTIR和XRD证明PLA和HA之间没有任何化学相互作用。热分析表明，HA可以减少PLA的结晶，但可以提高复合支架的热分解温度。此外，对PLA / HA复合支架的水接触角分析表明，亲水性随HA的添加而增加。此外，磷灰石形成能力测试证实，HA不仅可以更快地诱导弱羟基磷灰石的沉积，而且可以诱导HA的特定形态。