We studied the effects of stress exposure during the adolescent period of development (SAPD) on the parameters of inflammatory painful response and the level of depression-like behavior in prenatally stressed adult male rats. In addition, we analyzed the effects of selective serotonin (5-HT) reuptake inhibitor fluoxetine and 5-HT1A receptor agonist buspirone injected chronically to pregnant mothers for correction of behavioral disturbances caused by prenatal stress in their adult male progeny. In the formalin test, SAPD decreased integrated at the supraspinal level pain-like response that was increased by prenatal stress; under these conditions, buspirone and fluoxetine were ineffective in contrast to their antinociceptive action on spinally integrated pain-like response increased by SAPD. In the forced swimming test, SAPD had no effect on the level of depression-like behavior in prenatally stressed males; no differences in plasma corticosterone level were found in these animals.

中文翻译：

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青春期压力暴露对产前应激成年雄性大鼠炎症性疼痛反应、心理情绪行为和抗抑郁药作用的影响

我们研究了青春期发育期 (SAPD) 应激暴露对产前应激成年雄性大鼠炎症性疼痛反应参数和抑郁样行为水平的影响。此外，我们分析了选择性 5-羟色胺 (5-HT) 再摄取抑制剂氟西汀和 5-HT1A 受体激动剂丁螺环酮长期注射给怀孕母亲的效果，以纠正其成年男性后代因产前压力引起的行为障碍。在福尔马林试验中，SAPD 降低了脊髓上水平疼痛样反应的整合，产前压力增加了这种反应；在这些条件下，丁螺环酮和氟西汀与它们对 SAPD 增加的脊柱整合疼痛样反应的镇痛作用相比无效。在强迫游泳测试中，SAPD 对产前压力男性的抑郁样行为水平没有影响；在这些动物中没有发现血浆皮质酮水平的差异。