We studied the effects of stress exposure during the adolescent period of development (SAPD) on the parameters of inflammatory painful response and the level of depression-like behavior in prenatally stressed adult male rats. In addition, we analyzed the effects of selective serotonin (5-HT) reuptake inhibitor fluoxetine and 5-HT1A receptor agonist buspirone injected chronically to pregnant mothers for correction of behavioral disturbances caused by prenatal stress in their adult male progeny. In the formalin test, SAPD decreased integrated at the supraspinal level pain-like response that was increased by prenatal stress; under these conditions, buspirone and fluoxetine were ineffective in contrast to their antinociceptive action on spinally integrated pain-like response increased by SAPD. In the forced swimming test, SAPD had no effect on the level of depression-like behavior in prenatally stressed males; no differences in plasma corticosterone level were found in these animals.
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Butkevich IP, Mikhailenko VA, Vershinina EA, Semenov PO, Otellin VA. Effects of prenatal influences of buspirone and stress on indices of inflammatory pain response and depressive behaviour in adult rats. Ross. Fiziol. Zh. 2010;96(4):396-405. Russian.
Mikhailenko VА, Butkevich IP, Vershinina EA. Influence of Perinatal Stress and Antidepressants on the Acute and Tonic Pain Responses and Psycho-Emotional Behavior in Young Male Rats. Ross. Fiziol. Zh. 2019;105(7):888-901. Russian.
Butkevich I, Mikhailenko V, Vershinina E, Semionov P, Makukhina G, Otellin V. Maternal buspirone protects against the adverse effects of in utero stress on emotional and pain-related behaviors in offspring. Physiol. Behav. 2011;102(2):137-142.
Daskalakis NP, Bagot RC, Parker KJ, Vinkers CH, de Kloet ER. The three-hit concept of vulnerability and resilience: toward understanding adaptation to early-life adversity outcome. Psychoneuroendocrinology. 2013;38(9):1858-1873.
Marrocco J, Gray JD, Kogan JF, Einhorn NR, O’Cinneide EM, Rubin TG, Carroll TS, Schmidt EF, McEwen BS. Early life stress restricts translational reactivity in CA3 neurons associated with altered stress responses in adulthood. Front. Behav. Neurosci. 2019;13. ID 157. doi: https://doi.org/10.3389/fnbeh.2019.00157
McCormick CM, Mathews IZ, Thomas C, Waters P. Investigations of HPA function and the enduring consequences of stressors in adolescence in animal models. Brain Cogn. 2010;72(1):73-85.
Nederhof E, Schmidt MV. Mismatch or cumulative stress: toward an integrated hypothesis of programming effects. Physiol. Behav. 2012;106(5):691-700.
Spear LP. The adolescent brain and age-related behavioral manifestations. Neurosci. Biobehav. Rev. 2000;24(4):417-463.
Verstraeten BSE, McCreary JK, Weyers S, Metz GAS, Olson DM. Prenatal two-hit stress affects maternal and offspring pregnancy outcomes and uterine gene expression in rats: match or mismatch? Biol. Reprod. 2019;100(1):195-207.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 169, No. 3, pp. 277-280, March, 2020
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Butkevich, I.P., Mikhailenko, V.A. Effects of Stress Exposure during Adolescent Period on Inflammatory Pain Response, Psychoemotional Behavior, and Action of Antidepressants in Prenatally Stressed Adult Male Rats. Bull Exp Biol Med 169, 306–309 (2020). https://doi.org/10.1007/s10517-020-04875-w
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DOI: https://doi.org/10.1007/s10517-020-04875-w