2,6-Diisobornyl-4-methylphenol (Dibornol, 10 mg/kg intragastrically daily for 5 days after myocardial ischemia/reperfusion) 1.5-fold increased rat survival during the acute post-infarction period in comparison with the control group. In survivors, Dibornol reliably prevented post-ischemic progression of heart failure in the delayed post-infarction period (30 days after ischemia/reperfusion), which was seen from an increase in the left-ventricular developed pressure by 22%, left-ventricular contractility index by 19%, and +dP/dt by 34%. Left-ventricular end-diastolic pressure was by 39% lower than in control animals. Morphological study of heart sections from control group animals showed that Dibornol reduced the area of post-ischemic myocardial damage in the delayed period after ischemia/reperfusion to 3±1% (vs 18±2% in the control group).

中文翻译：

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2,6-二异冰片基-4-甲基苯酚减少大鼠缺血/再灌注后延迟期缺血后心肌重构

与对照组相比，2,6-二异冰片基-4-甲基苯酚（Dibornol，心肌缺血/再灌注后 5 天每天灌胃 10 毫克/千克）在急性梗死后期间使大鼠存活率增加 1.5 倍。在幸存者中，Dibornol 在延迟的梗死后时期（缺血/再灌注后 30 天）可靠地防止了心力衰竭的缺血后进展，这可以从左心室发展压力增加 22%、左心室收缩力中看出指数增加 19%，+dP/dt 增加 34%。左心室舒张末期压力比对照动物低 39%。对照组动物心脏切片的形态学研究表明，Dibornol 将缺血/再灌注后延迟期的缺血后心肌损伤面积减少至 3±1%（而对照组为 18±2%）。