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2,6-Diisobornyl-4-Methylphenol Reduces Postishemic Myocardium Remodeling in Delayed Period after Ischemia/Reperfusion in Rats

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2,6-Diisobornyl-4-methylphenol (Dibornol, 10 mg/kg intragastrically daily for 5 days after myocardial ischemia/reperfusion) 1.5-fold increased rat survival during the acute post-infarction period in comparison with the control group. In survivors, Dibornol reliably prevented post-ischemic progression of heart failure in the delayed post-infarction period (30 days after ischemia/reperfusion), which was seen from an increase in the left-ventricular developed pressure by 22%, left-ventricular contractility index by 19%, and +dP/dt by 34%. Left-ventricular end-diastolic pressure was by 39% lower than in control animals. Morphological study of heart sections from control group animals showed that Dibornol reduced the area of post-ischemic myocardial damage in the delayed period after ischemia/reperfusion to 3±1% (vs 18±2% in the control group).

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Authors and Affiliations

  1. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia

    G. A. Chernysheva & V. I. Smol’yakova

  2. Institute of Chemistry, Federal Research Center Komi Scientific Centre, Ural Division of the Russian Academy of Sciences, Syktyvkar, Russia

    A. V. Kutchin & I. Yu. Chukicheva

  3. Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia

    A. N. Osipenko & T. M. Plotnikova

Authors
  1. G. A. Chernysheva
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  2. V. I. Smol’yakova
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  3. A. V. Kutchin
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  4. I. Yu. Chukicheva
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  5. A. N. Osipenko
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  6. T. M. Plotnikova
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Corresponding author

Correspondence to T. M. Plotnikova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 169, No. 3, pp. 366-371, March, 2020

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Chernysheva, G.A., Smol’yakova, V.I., Kutchin, A.V. et al. 2,6-Diisobornyl-4-Methylphenol Reduces Postishemic Myocardium Remodeling in Delayed Period after Ischemia/Reperfusion in Rats. Bull Exp Biol Med 169, 310–313 (2020). https://doi.org/10.1007/s10517-020-04876-9

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  • DOI: https://doi.org/10.1007/s10517-020-04876-9

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