Autism is a prevalent developmental disorder that combines repetitive behaviours, social deficits and language abnormalities. The present study aims to assess the autistic subjects using DSM IV-TR criteria followed with the analysis of neurotransmitters, biochemical parameters, oxidative stress and its ions in two groups of autistic subjects (group I < 12 years; group II ≥ 12 years). Antioxidants show a variation of 10% increase in controls compared to autistic age < 12 years. The concentration of pyruvate kinase and hexokinase is elevated in controls approximately 60% and 45%, respectively, with the significance of 95 and 99%. Autistic subjects showed marked variation in levels of neurotransmitters, oxidative stress and its related ions. Cumulative assessment of parameters related to biochemical markers and neurotransmitters paves the way for autism-based research, although these observations draw interest in an integrated approach for autism.

自闭症是一种普遍的发育障碍，结合了重复性行为，社交缺陷和语言异常。本研究旨在使用DSM IV-TR标准评估自闭症受试者，然后分析两组自闭症受试者（I组<12岁； II组≥12岁）的神经递质，生化参数，氧化应激及其离子。与12岁以下的自闭症患者相比，抗氧化剂的对照品增加了10％。丙酮酸激酶和己糖激酶的浓度在对照中分别升高约60％和45％，显着性为95％和99％。自闭症患者的神经递质，氧化应激及其相关离子水平明显不同。