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Biomarker study of the biological parameter and neurotransmitter levels in autistics

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Abstract

Autism is a prevalent developmental disorder that combines repetitive behaviours, social deficits and language abnormalities. The present study aims to assess the autistic subjects using DSM IV-TR criteria followed with the analysis of neurotransmitters, biochemical parameters, oxidative stress and its ions in two groups of autistic subjects (group I < 12 years; group II ≥ 12 years). Antioxidants show a variation of 10% increase in controls compared to autistic age < 12 years. The concentration of pyruvate kinase and hexokinase is elevated in controls approximately 60% and 45%, respectively, with the significance of 95 and 99%. Autistic subjects showed marked variation in levels of neurotransmitters, oxidative stress and its related ions. Cumulative assessment of parameters related to biochemical markers and neurotransmitters paves the way for autism-based research, although these observations draw interest in an integrated approach for autism.

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Acknowledgements

The authors thank the Management of Bharathiar University for providing infrastructure facilities for this research work and the subjects who volunteered to take part in this study.

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Author notes

  1. Balamuralikrishnan Balasubramanian and Manikantan Pappusamy have equally contributed as first author.

Authors and Affiliations

  1. EuroEspes Biomedical Research Centre, International Center of Neurosciences and Genomic Medicine, Bergondo, 15165, Corunna, Spain

    Arun Meyyazhagan & Ramon Cacabelos

  2. Human Genetics Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore, Tamil Nadu, 641046, India

    Arun Meyyazhagan, Balamuralikrishnan Balasubramanian, Karthick Kumar Alagamuthu, Sureshkumar Shanmugam, Haripriya Kuchi Bhotla & Sasikala Keshavarao

  3. Department of Life Sciences, CHRIST (Deemed to be University), Bengaluru, Karnataka, 560029, India

    Arun Meyyazhagan & Manikantan Pappusamy

  4. Department of Food Science and Biotechnology, College of Life Science, Sejong University, Seoul, 05006, South Korea

    Balamuralikrishnan Balasubramanian

  5. Nutritional Improvement of Crops, International Centre for Genetic Engineering and Biotechnology, New Delhi, 110067, India

    Murugesh Easwaran, Arulprakash Thangaraj & Tanushri Kaul

  6. Department of Animal Resource and Science, Dankook University, Cheonan, 31116, South Korea

    Sureshkumar Shanmugam

  7. Jiagsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Nanjing, 210023, China

    Karthick Kumar Alagamuthu

  8. Medical Genetics and Epigenetics Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, Tamil Nadu, 641046, India

    Vijaya Anand Arumugam

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  1. Arun Meyyazhagan
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  2. Balamuralikrishnan Balasubramanian
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Correspondence to Arun Meyyazhagan.

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Meyyazhagan, A., Balasubramanian, B., Easwaran, M. et al. Biomarker study of the biological parameter and neurotransmitter levels in autistics. Mol Cell Biochem 474, 277–284 (2020). https://doi.org/10.1007/s11010-020-03851-2

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