Abstract

The antineoplastic properties of an antioxidant, sodium 2-carboxy-2-(N-acetylamino)-3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate, are studied on an ascites tumor, Sarcoma 37, and on a solid tumor, Lewis carcinoma. A full suppression of Sarcoma 37 and an intensification of apoptosis (a decrease in the level of Bcl-2 antiapoptotic protein) in the cells of Lewis carcinoma are observed for intraperitoneal injection of the preparation. The structure of the complexes of sodium 2-carboxy-2-(N-acetylamino)-3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate with peptides is calculated using quantum chemistry. Quantitative data are obtained which characterize the intra- and intermolecular interactions of the above components in nanoassociates.

中文翻译：

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水溶液中抗氧化剂2-羧基-2-（N-乙酰氨基）-3-（3,5-二叔丁基-4-羟基苯基）丙酸酯与肽的抗肿瘤性质及其相互作用机理量子化学方法计算的数据

摘要

研究了抗氧化剂2-羧基-2-（N-乙酰氨基）-3-（3,5-二叔丁基-4-羟基苯基）丙酸钠钠在腹水肿瘤肉瘤37和实体瘤，路易斯癌。对于腹膜内注射制剂，观察到路易斯癌细胞中肉瘤37的完全抑制和细胞凋亡的增强（Bcl-2抗凋亡蛋白水平的降低）。使用量子化学计算2-羧基-2-（N-乙酰氨基）-3-（3,5-二叔丁基-4-羟基苯基）丙酸钠钠与肽的配合物的结构。获得定量数据，其表征了纳米缔合物中上述组分的分子内和分子间相互作用。