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The Antineoplastic Properties and Mechanism of Interaction of an Antioxidant, Sodium 2-Carboxy-2-(N-Aсetylamino)-3-(3,5-di-tert-Butyl-4-Hydroxyphenyl)Propionate, with Peptides in an Aqueous Environment According to the Data of the Calculation by Quantum Chemistry Methods

  • CHEMICAL PHYSICS OF BIOLOGICAL PROCESSES
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Abstract

The antineoplastic properties of an antioxidant, sodium 2-carboxy-2-(N-acetylamino)-3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate, are studied on an ascites tumor, Sarcoma 37, and on a solid tumor, Lewis carcinoma. A full suppression of Sarcoma 37 and an intensification of apoptosis (a decrease in the level of Bcl-2 antiapoptotic protein) in the cells of Lewis carcinoma are observed for intraperitoneal injection of the preparation. The structure of the complexes of sodium 2-carboxy-2-(N-acetylamino)-3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate with peptides is calculated using quantum chemistry. Quantitative data are obtained which characterize the intra- and intermolecular interactions of the above components in nanoassociates.

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Authors and Affiliations

  1. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119334, Moscow, Russia

    A. A. Volodkin, V. N. Erokhin, E. M. Mil, A. A. Albantova & V. I. Binyukov

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  1. A. A. Volodkin
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  2. V. N. Erokhin
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  3. E. M. Mil
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  4. A. A. Albantova
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  5. V. I. Binyukov
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Correspondence to A. A. Volodkin.

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Translated by E. Boltukhina

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Volodkin, A.A., Erokhin, V.N., Mil, E.M. et al. The Antineoplastic Properties and Mechanism of Interaction of an Antioxidant, Sodium 2-Carboxy-2-(N-Aсetylamino)-3-(3,5-di-tert-Butyl-4-Hydroxyphenyl)Propionate, with Peptides in an Aqueous Environment According to the Data of the Calculation by Quantum Chemistry Methods. Russ. J. Phys. Chem. B 14, 443–449 (2020). https://doi.org/10.1134/S1990793120030136

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  • DOI: https://doi.org/10.1134/S1990793120030136

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